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The importance of experimental work for current medical practice. Experiments on Cell Cultures. Experiments on Animals. Management of animal experimentation - ethical aspects of animal experiments. Historical Development, The Rule of the Three R.
The history of the use of experimental and laboratory animals: Ancient Cultures, Egypt and the Hebrew Civilisation, ancient Greece. The Deterioration of Mediaeval Medicine. The Renaissance of Medicine, the Medicine of the Renaissance. The Birth of Experiment. The Establishment of Modern Scientific Approaches.
Legal standards relating to the protection of experimental animals. Introduction to biology ane breeding of experimental and laboratory animals. Basic Needs of Laboratory Animals. Systems of Breeding Experimental Animals. Genetic Characteristics of Experimental Animals. Characteristics of Well-Known Experimentally Used Species.
Anesthesia of experimental animals. Drug administration, anesthesia care, preoperative preparation. Introduction, basic Anesthetic Methods and Techniques, types of anesthesia care and possibilities of their induction. Methods of drug administration.
Basic Overview of Agents for Anesthesia in Laboratory Animals, Anesthetics - Thiopental, Propofol, Ketamine, Volatile anesthetics, Benzodiazepines, Antipsychotics. Analgesics - Opioid analgesics, Fentanyl and Long-acting analgesics, Non-opioid analgesics. Basic Preparation of Laboratory Animals for Anesthesia.
Monitoring and support of vital functions during anesthesia of laboratory animals. Basic Clinical Monitoring of Animal under Anesthesia. Monitoring of ventilation and oxygenation. Monitoring of cardiovascular system. Values of Basic Vital Functions in Different Animal Species. Ventilatory Support and Monitoring of Pulmonary Function.
Extended Monitoring of Hemodynamics and Perfusion of Individual Organs - Thermodilution principle, Ultrasonographic approach, Pulse waveform analysis. Laboratory Methods. Experimental Methods. Monitoring of tissue oxygen. Monitoring of microcirculation.
Analgesia, Pain and its manifestation in experimental animals. Drugs used for pain relief - Regional techniques, Opioid analgesics, Non-opioid analgesics. Postoperative Care. Euthanasia - Basic ethical principles, Applicable methods (Chemical methods, Mechanical methods).
Anesthesia, analgesia, postooperative care. Anesthesia of Small Laboratory Animals. General advantages and disadvantages of using small animals in laboratory experiments. Anesthetic procedures in small animals. Anesthesia of Large Laboratory Animals. Basic procedure and induction of anesthesia. Intensive care in animal experiments.
Basic rules of surgical work. Asepsis and antisepsis. Surgical hand Scrubbing. Preparation of the Surgical Field. Dressing into Surgical Gown and Glowes. Drapping of the Surgical Field.
1 Preparation for Surgery and the Arrangement of the Operating Theatre. Hemostasis. Preparation. The Technique of Knotting. The Technique of Sewing an Anastomosis. Drainage.
In the previous presentation the terms disinfection and sterile material were used. Now their meaning will be explained. Disinfection, Sterilization, Physical sterilization with dry heat, Physical sterilization with wet heat, Physical sterilization with radiation, Sterilization with gas (plasma), Chemical sterilization
Postoperative care in experimental surgery is limited by the environment in which the animals are held. Basic postoperative care includes maintaining the airway patency by leaving the tracheal tube in until complete recovery from the anesthesia, and it also comprises analgesia, which leads to early mobilisation of the animal.
The Effect of Cytokines and Growth Factors on the Regeneration of the Liver, Embolisation of the Portal Vein Branch, The Methods of the Experimental Study of the Ligation of the Right Branch of the Portal Vein, The Results of the Study, Conclusions of the Study.
Early application monoclonal of the antibody against the transforming growth factor beta-1 before extensive resection surgery of the liver - experiment on a large animal. The Phase Before the Resection. The Resection Phase and the Postsurgical Period. Termination of the Experiment. Statistical Analysis. Protocol for the Experimental Model of the Regeneration of the Liver Parenchyma - Biological Therapy-the Inhibition of TGFβ-1.
Surgery starts with a skin incision. The incision should always be placed in the direction of the grain of the skin. The correct localisation of the wound is also important for the experimental animal because the surrounding tissues are damaged less. The names of the approaches are derived from the approached cavities, for example, craniotomy, thoracotomy and laparotomy.
Experimental model of liver regeneration in a toxically damaged liver parenchyma, experiment on a domestic pig. The Metabolism of Amino Acids, Carbohydrates and Lipids in the Liver. Steatohepatitis. Alcoholic Steatohepatitis ASH. Non-Alcoholic Steatohepatitis - NASH. Chemotherapy-Associated Steatohepatitis - CASH. Transforming Growth Factor Beta (TGF-β).
Experimental model of biliary obstruction - a pilot study. Introduction. Surgery. Postsurgical Period. Biochemistry. Ultrasonography. Termination of Experiment and Results.